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Table 2 Quantification of the neuropathological changes. Amyloid (A)β and hyperphosphorylated (p)tau loads (%) in control and Alzheimer’s disease cases detected by immunohistochemistry

From: Systemic infection modifies the neuroinflammatory response in late stage Alzheimer’s disease

Protein load (%) Ctrl- Ctrl+ AD- AD+ Mean difference (95% CI) P value
Aβ load 2.66 ± 3.38 2.97 ± 3.91 7.49 ± 3.37 6.46 ± 2.95 4.15 (2.82, 5.48) < 0.001
pTau 0.01 ± 0.20 0.04 ± 0.11 2.20 ± 3.52 2.02 ± 2.20 2.09 (1.18, 2.98) < 0.001
  1. Values are mean ± SD; p value by 2-way ANOVA test; significant p value in italic
  2. Ctrl neurologically/cognitively normal controls, AD Alzheimer’s disease cases, − died without infection, + died with infection, SD standard deviation, CI confidence interval