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Table 2 Quantification of the neuropathological changes. Amyloid (A)β and hyperphosphorylated (p)tau loads (%) in control and Alzheimer’s disease cases detected by immunohistochemistry

From: Systemic infection modifies the neuroinflammatory response in late stage Alzheimer’s disease

Protein load (%)

Ctrl-

Ctrl+

AD-

AD+

Mean difference (95% CI)

P value

Aβ load

2.66 ± 3.38

2.97 ± 3.91

7.49 ± 3.37

6.46 ± 2.95

4.15 (2.82, 5.48)

< 0.001

pTau

0.01 ± 0.20

0.04 ± 0.11

2.20 ± 3.52

2.02 ± 2.20

2.09 (1.18, 2.98)

< 0.001

  1. Values are mean ± SD; p value by 2-way ANOVA test; significant p value in italic
  2. Ctrl neurologically/cognitively normal controls, AD Alzheimer’s disease cases, − died without infection, + died with infection, SD standard deviation, CI confidence interval
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Acta Neuropathologica Communications

ISSN: 2051-5960

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