Table 1 Demographic, clinical and post-mortem characteristics of controls and Alzheimer’s cases
From: Systemic infection modifies the neuroinflammatory response in late stage Alzheimer’s disease
Cases | Ctrl- (n = 24) | Ctrl+ (n = 16) | AD- (n = 28) | AD+ (n = 40) |
|---|---|---|---|---|
Gender | 12F:12M | 7F:9M | 16F:12M | 25F:15M |
Age of Death (years, mean±SD) | 80.4±10.4 | 82.1±9.5 | 81.1±6.1 | 82±7.4 |
Age of AD onset (years, mean±SD) | n/a | n/a | 72.7±7.7 | 74.3±8.9 |
Duration of AD (years, mean±SD) | n/a | n/a | 8.4±4.3 | 7.7±4.0 |
Braak Stage | 0-II: 18 | 0-II: 11 | 0-II: 0 | 0-II: 0 |
III-IV: 2 | III-IV: 2 | III-IV: 6 | III-IV: 6 | |
V-VI: 0 | V-VI: 0 | V-VI: 22 | V-VI: 34 | |
Cause of death | ||||
Cardiovascular disease | 20/24 (83.3%) | 7/28 (25%) | ||
Non-brain tumour | 2/24 (8.3%) | 5/28 (17.9%) | ||
Other | a2/24 (8.3%) | a2/16 (12.5%) | b16/28 (57.1%) | a3/40 (7.5%) |
Bronchopneumonia | 12/16 (75%) | 32/40 (80%) | ||
Urinary Tract Infection | 2/16 (12.5%) | 5/40 (12.5%) | ||
APOE genotype | ||||
ε4/− | 2/19 (10.5%) | 2/10 (20%) | 9/23 (39.1%) | 15/36 (41.7%) |
ε4/ε4 | 1/19 (5.3%) | 0/10 (0%) | 5/23 (21.7%) | 8/36 (22.2%) |
Post-mortem delay (hours, mean±SD) | 34.6±18.5 | 50.1±27.4 | 37.8±26.8 | 48.2±23.3 |
pH | n/a | n/a | 6.1±0.4 | 6.1±0.3 |