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Table 1 Demographic, clinical and post-mortem characteristics of controls and Alzheimer’s cases

From: Systemic infection modifies the neuroinflammatory response in late stage Alzheimer’s disease

Cases Ctrl-
(n = 24)
Ctrl+
(n = 16)
AD-
(n = 28)
AD+
(n = 40)
Gender 12F:12M 7F:9M 16F:12M 25F:15M
Age of Death (years, mean±SD) 80.4±10.4 82.1±9.5 81.1±6.1 82±7.4
Age of AD onset (years, mean±SD) n/a n/a 72.7±7.7 74.3±8.9
Duration of AD (years, mean±SD) n/a n/a 8.4±4.3 7.7±4.0
Braak Stage 0-II: 18 0-II: 11 0-II: 0 0-II: 0
III-IV: 2 III-IV: 2 III-IV: 6 III-IV: 6
V-VI: 0 V-VI: 0 V-VI: 22 V-VI: 34
Cause of death
Cardiovascular disease 20/24 (83.3%)   7/28 (25%)  
Non-brain tumour 2/24 (8.3%)   5/28 (17.9%)  
Other a2/24 (8.3%) a2/16 (12.5%) b16/28 (57.1%) a3/40 (7.5%)
Bronchopneumonia   12/16 (75%)   32/40 (80%)
Urinary Tract Infection   2/16 (12.5%)   5/40 (12.5%)
APOE genotype
ε4/− 2/19 (10.5%) 2/10 (20%) 9/23 (39.1%) 15/36 (41.7%)
ε4/ε4 1/19 (5.3%) 0/10 (0%) 5/23 (21.7%) 8/36 (22.2%)
Post-mortem delay (hours, mean±SD) 34.6±18.5 50.1±27.4 37.8±26.8 48.2±23.3
pH n/a n/a 6.1±0.4 6.1±0.3
  1. Ctrl neurologically/cognitively normal controls, AD Alzheimer’s disease, − died without systemic infection, + died with systemic infection, F female, M male, RIN RNA integrity number, n/a not-applicable, SD standard deviation
  2. Braak staging and APOE genotyping were not available for all cases
  3. other cause of death included: abowel obstruction, ruptured abdominal aortic aneurysm, fall (fractured femur); bAlzheimer’s disease