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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Hypoxic pre-conditioning suppresses experimental autoimmune encephalomyelitis by modifying multiple properties of blood vessels

Fig. 4

CMH protects against loss of the endothelial tight junction proteins ZO-1 and occludin during EAE. a and c. Frozen sections of lumbar spinal cord taken from disease-free, EAE-normoxia or EAE-CMH mice at the peak symptomatic phase of EAE were stained for CD31 (AlexaFluor-488) and ZO-1 (Cy-3) in panel A or CD31 (AlexaFluor-488) and occludin (Cy-3) in panel C. Scale bar = 100 μm (inset, scale bar = 50 μm). b and d. Quantification of ZO-1 (b) and occludin expression (d). Results are expressed as the mean ± SEM (n = 6 mice/group). Note that CMH protected against loss of ZO-1 and occludin. ** p < 0.01

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