Fig. 4

Analysis of metabolites in the CSF from IDH-mutant and IDH-WT gliomas. a Heat map showing differences in metabolites in the CSF of controls versus patients with IDH-mutant gliomas. b Heat map showing differences in CSF metabolites between controls and IDH-WT gliomas. c Heat map showing differences in CSF metabolites between IDH-mutant and IDH-WT gliomas. d Nine metabolites are significantly associated with the presence of the IDH-mutation in gliomas (1-Methyltryptophan, 1-Methyl-Histidine, Arginine, N-Acetylputrescine, Succinic acid semialdehyde, Malonate, betaine aldehyde, Pantothenic acid). e In addition, D-2-HG concentration is higher in the CSF of patients with IDH-mutant gliomas