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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Rapid dissemination of alpha-synuclein seeds through neural circuits in an in-vivo prion-like seeding experiment

Fig. 6

Different modes of a-syn transmission and propagation. a Schematic representation of the step-by-step mode, whereby misfolded a-syn propagation forms aggregates, and then seeds are released in a neuron, and finally the seeds are transmitted to a connected neuron via the synapse. b Schematic representation for the dissemination mode, whereby seeds are disseminated transneuronally and induce the propagation of misfolded a-syn to form aggregates in the disseminated areas. a-Syn seeds are transmitted trans-synaptically, indicating inhibition due to injection of BoNT/B

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Acta Neuropathologica Communications

ISSN: 2051-5960

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