Skip to main content
Fig. 7 | Acta Neuropathologica Communications

Fig. 7

From: Anti-tau conformational scFv MC1 antibody efficiently reduces pathological tau species in adult JNPL3 mice

Fig. 7

Soluble, oligomeric and insoluble tau. a, b, c Phosphorylated soluble tau levels (hsp: heat stable preparation) in the hippocampus, cortex and HB: pThr231 tau was significantly reduced in the hippocampus (*P = 0.036 by one-way ANOVA) and cortex (*P = 0.0351 by one-way ANOVA) when the astrocytic system was employed (GFAF-scFvMC1); in the cortex, a trend towards reduction was observed when neurons were targeted (CAG-scFvMC1, P = 0.0614); in the HB, pThr231 was reduced with either promoter (CAG-scFvMC1 *P = 0.0237, GFAP-scFvMC1 *P = 0.0408 by one-way ANOVA). d, e, f Oligomeric/aggregated tau species quantified in hippocampus, cortex and HB: oligomeric tau was significantly decreased in the hippocampus both under neuronal (**P = 0.004 by one-way ANOVA) or astrocytic expression (***P = 0.0004 by one-way ANOVA); oligomeric tau in the HB was significantly reduced only when using the GFAP-scFvMC1 system (*P = 0.0444 by one-way ANOVA); no modulation of oligomeric tau species was found in the cortex. g, h Insoluble tau (INS) was analyzed in the cortex and HB: no changes were detected in the cortex, while the HB showed a significant reduction under the expression of the GFAP promoter (*P = 0.0378 by non-parametric Kruskall-Wallis test). All graphs are means +/− SEM (n = 15 in each group of treatment)

Back to article page