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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Anti-tau conformational scFv MC1 antibody efficiently reduces pathological tau species in adult JNPL3 mice

Fig. 3

AAV5-scFv-MC1 cellular selectivity. Representative immunofluorescent confocal images of the hippocampus (CA1 quadrant) from JNPL3 mice. a-e When mice were injected with AAV5-CAG-scFvMC1 (n = 6), the scFv was expressed mainly in neurons: scFv-MC1 (a, Myc-red), MAP2-positive neurons (b, green), GFAP-positive astrocytes (c, magenta); co-localization is shown as merge of red and green (e, orange/yellow). f-j Upon injection with AAV5-GFAP-scFvMC1 (n = 6), scFvMC1 was expressed primarily in astrocytes: scFv-MC1 (f, Myc-red), GFAP-positive astrocytes (g, green), NeuN-positive neurons (h, magenta); co-localization is shown as merge of red and green (j, yellow). Nuclei were stained with DAPI (blue, panel d and i). Images represent maximum-intensity projection of z-stacks (Zeiss 880 confocal laser miscroscope, bar: 50 μm)

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