Fig. 2

AAV5-scFv-MC1 transduction in vivo. a Representative images of JNPL3 mice brain sections, 4 weeks post injection (n = 6): the AAV5-scFv-MC1 injected brain showed clear expression of the recombinant antibody in the hippocampus using an anti-Myc antibody (red). Nuclei were stained with DAPI (blue). No signal was detected in the not injected brains (Zeiss Axio Imager Apotome, bar: 500 μm). b western blotting on hippocampus lysates of injected (Inj.) or not-injected (Not Inj.) JNPL3 mice, using anti-Myc antibody. Neuronal N-cadherin was used as a marker of neuronal integrity, and actin was used as a housekeeper