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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: PrPres deposition in the retina is a common finding of sporadic, familial and iatrogenic Creutzfeldt-Jakob diseases (CJD)

Fig. 1

a. Representative images of PrP immunohistochemistry of retinas in Creutzfeldt-Jakob disease. 3F4 and 12F10 immunoreactive deposits are present in the OPL and IPL. 12F10 immunoreactive deposits stain more strongly than those of 3F4. In particular, cases of MM2, MM1 + 2, V180I, M232R, and dCJD show 3F4 and 12F10 immunoreactive fine deposits in the INL, ONL, GCL, and NFL. B. 3F4 and 12F10 immunoreactive deposits are consistently observed in the OPL and IPL. ONL: outer nuclear layers, OPL: outer plexiform layer, INL: inner nuclear layer, IPL: inner plexiform layer, GCL: ganglion cell layer, NFL: nerve fiber layer. b. Frequency of PrP immunoreactivity of each anatomical region in the retina. Fine-dot PrPres-irs staining was occasionally observed in the INL, ONL, and NFL. Staining was more consistent in cases of MM2, fCJD, and dCJD

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Acta Neuropathologica Communications

ISSN: 2051-5960

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