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Fig. 8 | Acta Neuropathologica Communications

Fig. 8

From: Neutrophil elastase inhibition effectively rescued angiopoietin-1 decrease and inhibits glial scar after spinal cord injury

Fig. 8

Sivelestat treatment improved motor functions and attenuated neuropathic pain after spinal cord injury (SCI). a Representative footprints of animal walking 1, 7, 14, 21 and 28 days after SCI. Black: Left forepaw footprints; Blue: Right forepaw footprints; Purple: left hind paw footprints; Red: Right hind paw footprints. b Functional recovery was then assessed in open-field testing by using the 21-point Basso, Beattie, and Bresnahan (BBB) locomotor test at 1, 7, 14, 21 and 28 days after SCI. c Nociception was evaluated using Von Frey-filaments; SCI-induced hypersensitivity (decrease in withdrawal threshold) was assessed at 1, 7, 14, 21 and 28 days after SCI (sham = 6, injury = 16 and sivelestat = 12 for behavioral experiments). Representative sections of ANGPT-1 and PECAM (d), neurotrophin-3 (NT-3) and Glial fibrillary acidic protein (GFAP) (e), and neurotrophin-4 (NT-4) and Brain-derived neurotrophic factor (BDNF) (f), at DPI-28. Data represent means ± S.E.M. #p < 0.05, ###p < 0.001 vs. sham group. ***p < 0.001 vs. Injury group

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