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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: RNA binding proteins co-localize with small tau inclusions in tauopathy

Fig. 3

RNA binding proteins become insoluble in the cortex of rTg4510 mice. (a, b) Immunoblots of the sarkosyl soluble (S3) and insoluble (P3) fractions isolated from rTg4510 cortical tissues indicate that many RBPs become insoluble as tau pathology develops. The fractions were also probed for TDP-43, which is not associated with tau aggregation. Quantification of these immunoblots (c, d) shows statistically significant RBP accumulation in the P3 fraction of induced rTg4510 mouse cortex using a two-tailed t-test (p = 0.00599 for TAOK1; p = 0.0007599 for EWSR1; p = 0.0122 for TAF15; p = 0.000252 for RPL7; p = 0.00195 for PABP; p = 0.0926 for DDX5; p = 0.0638 for HNRNPA0)

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