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Table 1 γH2AX-binding genomic regions specifically enriched in PDDF from cortical neurons and related to human genes implicated in neurological and neuropsychiatric disorders

From: Persistent accumulation of unrepaired DNA damage in rat cortical neurons: nuclear organization and ChIP-seq analysis of damaged DNA

Gene Encoded protein Fold change Relation to human pathology Reference
aga Aspartylglucosaminidase 2.875 Aspartylglucosaminuria (0.69) [34]
appl2 Adaptor protein containing Ph domain, Ptb domain and leucine zipper motif 2 3.31 Substance adiction (0.2) [18]
cdh10 Cadherin 10 2.88 Autism (0.2) [78]
epm2a Laforin glucan phosphatase 2.25 Lafora disease (0.71), progressive myoclonus epilepsy (0.407) [1, 24]
fbxo30/fbxw7 F-box/WD repeat containing protein 7 2.25 Glioma (0.127), genome instability (0.12) [8, 75]
gria1 Glutamate receptor 1 3.72 Schizophrenia (0.208), Bipolar Disorder (0.206), Mental Depression and Depressive disorder (0.201), learning and memory disorders (0.2) [10, 40, 51, 70]
gria2 Glutamate receptor 1 2.69 Schizophrenia (0.209), Bipolar Disorder (0.203), Depressive disorder (0.201) [9,10,11]
htr1a Serotonin 5-Ht-1A receptor 1A 2.72 Mental Depression and Depressive disorder (0.253), Schizophrenia (0.221) [42, 77]
il1b Interleukin 1-β 2.39 Alzheimer disease (0.369) [80]
il1rapl1 Interleukin 1 receptor accessory protein-like 1 2.375 Autism (0.404), Mental retardation (0.205) [30, 66]
lbr Lamin b receptor 2.39 Reynold syndrome (0.6) [25]
rab38 Ras-related protein Rab-38 3.38 Frontotemporal dementia (0.12) [20]
scn4a Sodium channel protein type 4 subunit alpha 3.19 Hyperkalemic periodic paralysis (0.688), Potassium-aggravated myotonia (0.602), Hypokalemic periodic paralysis type 2 (0.48), Hypokalemic periodic paralysis type 1 (0.41), Congenital paramyotonia (0.408), Fluctuating myotonia (0.24), Myotonia (0.405) [6]
serpini1 Neuroserpin 2.88 Familial encephalopathy with neuroserpin inclusion bodies (0.681), Dementia (0.208), Progressive myoclonus epilepsy (0.203) [15]
sugct Succinyl-CoA; Glutarate-CoA transferase 3.71 Migraine (0.24) [63]
tkt Transketolase 2.23 Wernicke-Korsakoff syndrome, Wernicke encephalopaty (0.201) [14]
  1. The number in brackets that appears next to the name of diseases corresponds to the “Score of the reliability of the gene-disease pair, based on the type and number of sources where is reported, and the number of PMIDs”