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Table 1 γH2AX-binding genomic regions specifically enriched in PDDF from cortical neurons and related to human genes implicated in neurological and neuropsychiatric disorders

From: Persistent accumulation of unrepaired DNA damage in rat cortical neurons: nuclear organization and ChIP-seq analysis of damaged DNA

Gene

Encoded protein

Fold change

Relation to human pathology

Reference

aga

Aspartylglucosaminidase

2.875

Aspartylglucosaminuria (0.69)

[34]

appl2

Adaptor protein containing Ph domain, Ptb domain and leucine zipper motif 2

3.31

Substance adiction (0.2)

[18]

cdh10

Cadherin 10

2.88

Autism (0.2)

[78]

epm2a

Laforin glucan phosphatase

2.25

Lafora disease (0.71), progressive myoclonus epilepsy (0.407)

[1, 24]

fbxo30/fbxw7

F-box/WD repeat containing protein 7

2.25

Glioma (0.127), genome instability (0.12)

[8, 75]

gria1

Glutamate receptor 1

3.72

Schizophrenia (0.208), Bipolar Disorder (0.206), Mental Depression and Depressive disorder (0.201), learning and memory disorders (0.2)

[10, 40, 51, 70]

gria2

Glutamate receptor 1

2.69

Schizophrenia (0.209), Bipolar Disorder (0.203), Depressive disorder (0.201)

[9,10,11]

htr1a

Serotonin 5-Ht-1A receptor 1A

2.72

Mental Depression and Depressive disorder (0.253), Schizophrenia (0.221)

[42, 77]

il1b

Interleukin 1-β

2.39

Alzheimer disease (0.369)

[80]

il1rapl1

Interleukin 1 receptor accessory protein-like 1

2.375

Autism (0.404), Mental retardation (0.205)

[30, 66]

lbr

Lamin b receptor

2.39

Reynold syndrome (0.6)

[25]

rab38

Ras-related protein Rab-38

3.38

Frontotemporal dementia (0.12)

[20]

scn4a

Sodium channel protein type 4 subunit alpha

3.19

Hyperkalemic periodic paralysis (0.688), Potassium-aggravated myotonia (0.602), Hypokalemic periodic paralysis type 2 (0.48), Hypokalemic periodic paralysis type 1 (0.41), Congenital paramyotonia (0.408), Fluctuating myotonia (0.24), Myotonia (0.405)

[6]

serpini1

Neuroserpin

2.88

Familial encephalopathy with neuroserpin inclusion bodies (0.681), Dementia (0.208), Progressive myoclonus epilepsy (0.203)

[15]

sugct

Succinyl-CoA; Glutarate-CoA transferase

3.71

Migraine (0.24)

[63]

tkt

Transketolase

2.23

Wernicke-Korsakoff syndrome, Wernicke encephalopaty (0.201)

[14]

  1. The number in brackets that appears next to the name of diseases corresponds to the “Score of the reliability of the gene-disease pair, based on the type and number of sources where is reported, and the number of PMIDs”
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Acta Neuropathologica Communications

ISSN: 2051-5960

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