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Fig. 10 | Acta Neuropathologica Communications

Fig. 10

From: Optic nerve as a source of activated retinal microglia post-injury

Fig. 10

Detection of Ki67+ cells in the optic nerve and retina. a Rare Ki67+ cells found in retinal flatmounts of CD11cGFP mice at 6 days post-ONC. b Analysis of the optic nerve of B6 mice 7 days post-ONC revealed Ki67+ cells; some were also CD11b+. c Onset of retinal inflammation in the R161 spontaneous murine model of autoimmune uveitis in R161H x CD11cGFP mice on the (B10.R3 x B6)F1 background revealed extensive cell proliferation in retinal flatmounts prepared from eyes harvested at 111 days of age. (F) Many Ki67+ cells were found in the central retina near the optic nerve head, including some that co-stained with CD11b. (G) Smaller numbers of Ki67+ cells were found in the periphery of the opposite, inflamed retina. d Counts of Ki67+ cells in crushed ON. Sixteen micron thick sections were cut and stained. Non-parametric statistic done with Kruskal-Wallis H test analysis. *, p < 0.05; **, p < 0.01

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