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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Optic nerve as a source of activated retinal microglia post-injury

Fig. 1

An optic nerve crush (ONC) injury stimulated appearance of GFPhiYFPhi myeloid cells in the retina of CX3CR1YFP-creER:CD11cGFP mice. a Time course of post-ONC loss of RGC comparing self-closing forceps with DSAEK forceps. Gray shaded area at top of graph represents the normal number of RGC/field ±1 SD. Area of field = 0.19 mm2. (Red: DSAEK forceps; Blue: #N7 self-closing forceps.) b Fluorescence fundus photos detecting the expression of GFP from GFPhi myeloid cells. The same retina at 2 days and 6 days post-ONC is shown. c Representative flow cytometry results of analyses of GFPhi and GFPlo populations of retinal myeloid cells (gated on viable, doublet-excluded CD45medCD11b+Ly6G cells). d Time course of the appearance of GFPhi myeloid cells and GFPlo microglia in retina after an acute ONC injury. Average of 4–9 retinas per time point

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