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Table 2 Characteristics of survivors of pediatric medulloblastoma who developed radiation-associated DIPG

From: Medulloblastoma therapy generates risk of a poorly-prognostic H3 wild-type subgroup of diffuse intrinsic pontine glioma: a report from the International DIPG Registry

  Primary Medulloblastoma Radiation-associated DIPG
Case number - location Age at diagnosis (years) Gender Risk stratification Histology, subgroup Time in remission (years) Age at diagnosis (years) Treatment Histology (sequencing) Outcome (months after DIPG diagnosis)
1 - IDIPGR (Michigan Medicine) 8 F Average Classic, Group 4 (isochromosome 17q) 12 21 54 Gy focal radiation treatment, panobinostat High-grade glioma (TP53 loss, PTEN loss, NRAS mutation) Died of disease (17)
2 - IDIPGR (Michigan Medicine) 9 M Average Classic, Group 3/4 7 16 Patient declined Biopsy deferred Died of disease (4)
3 - IDIPGR (Michigan Medicine) 4 M High Classic, Group 3 4 9 35 Gy focal radiation treatment, everolimus High-grade glioma (PIK3CA and EZH2 mutations) Living (5)
4 - IDIPGR (Hospital for Sick Children) 2 M High Classic, Group 3 2 7 Etoposide, temozolomide, mechlorethamine, cyclophosphamide Not reported Died of disease (5)
5 - IDIPGR (Seattle Children’s Hospital) 6 M Average Classic, Group 4 10 17 Temozolomide Not biopsied; diagnosis made by imaging Died of disease (10)
6 - IDIPGR (Princess Margaret Hospital for Children) 4 M High Classic, Group 4 11 15 Focal radiation treatment, vorinostat High-grade glioma (PIK3CA mutation) Died of disease (8)
7- Packer et al. 2013 [31] (COG A9961) 3–21 Not reported Average Not reported 6.5 Not reported Not reported Pilocytic astrocytomaa Died of disease (10)
8 - Packer et al. 2013 [31] (COG A9961) 3–21 Not reported Average Not reported 9 Not reported Not reported Biopsy deferred Not reported
9 - Von Hoff et al. 2009 [42] (HIT’91) 3–18 Not reported Not reported Not reported Not reported Not reported Not reported Not reported Not reported
10 - Sabel et al. 2016 [36] (HIT-SIOP-PNET4) 4–21 Not reported Average Not reported 5.1 Not reported Not reported Anaplastic astrocytoma Died of disease (Not reported)
11 - Packer et al. 1999 [30] (CCG 9892) 3–10 Not reported Average Not reported 4.8 Not reported Not reported Glioma, grade unspecified Died of disease (Not reported)
12 - You et al. 2013 [46] (Yonsei Hospital) 8 M Not reported Not reported 7.8 Not reported Temozolomide Anaplastic astrocytoma Died of disease (6)
  1. aPathology was not reviewed centrally by trial