Table 2 Characteristics of survivors of pediatric medulloblastoma who developed radiation-associated DIPG
| Â | Primary Medulloblastoma | Radiation-associated DIPG | |||||||
|---|---|---|---|---|---|---|---|---|---|
Case number - location | Age at diagnosis (years) | Gender | Risk stratification | Histology, subgroup | Time in remission (years) | Age at diagnosis (years) | Treatment | Histology (sequencing) | Outcome (months after DIPG diagnosis) |
1 - IDIPGR (Michigan Medicine) | 8 | F | Average | Classic, Group 4 (isochromosome 17q) | 12 | 21 | 54Â Gy focal radiation treatment, panobinostat | High-grade glioma (TP53 loss, PTEN loss, NRAS mutation) | Died of disease (17) |
2 - IDIPGR (Michigan Medicine) | 9 | M | Average | Classic, Group 3/4 | 7 | 16 | Patient declined | Biopsy deferred | Died of disease (4) |
3 - IDIPGR (Michigan Medicine) | 4 | M | High | Classic, Group 3 | 4 | 9 | 35Â Gy focal radiation treatment, everolimus | High-grade glioma (PIK3CA and EZH2 mutations) | Living (5) |
4 - IDIPGR (Hospital for Sick Children) | 2 | M | High | Classic, Group 3 | 2 | 7 | Etoposide, temozolomide, mechlorethamine, cyclophosphamide | Not reported | Died of disease (5) |
5 - IDIPGR (Seattle Children’s Hospital) | 6 | M | Average | Classic, Group 4 | 10 | 17 | Temozolomide | Not biopsied; diagnosis made by imaging | Died of disease (10) |
6 - IDIPGR (Princess Margaret Hospital for Children) | 4 | M | High | Classic, Group 4 | 11 | 15 | Focal radiation treatment, vorinostat | High-grade glioma (PIK3CA mutation) | Died of disease (8) |
7- Packer et al. 2013 [31] (COG A9961) | 3–21 | Not reported | Average | Not reported | 6.5 | Not reported | Not reported | Pilocytic astrocytomaa | Died of disease (10) |
8 - Packer et al. 2013 [31] (COG A9961) | 3–21 | Not reported | Average | Not reported | 9 | Not reported | Not reported | Biopsy deferred | Not reported |
9 - Von Hoff et al. 2009 [42] (HIT’91) | 3–18 | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported | Not reported |
10 - Sabel et al. 2016 [36] (HIT-SIOP-PNET4) | 4–21 | Not reported | Average | Not reported | 5.1 | Not reported | Not reported | Anaplastic astrocytoma | Died of disease (Not reported) |
11 - Packer et al. 1999 [30] (CCG 9892) | 3–10 | Not reported | Average | Not reported | 4.8 | Not reported | Not reported | Glioma, grade unspecified | Died of disease (Not reported) |
12 - You et al. 2013 [46] (Yonsei Hospital) | 8 | M | Not reported | Not reported | 7.8 | Not reported | Temozolomide | Anaplastic astrocytoma | Died of disease (6) |