Table 1 Observed cumulative incidence of radiation-associated malignancies in survivors of pediatric medulloblastoma
Source | Population | Size of cohort | Number of secondary malignant neoplasms | Number of gliomas | Number of DIPG (cumulative incidence %) | Median follow-up (years) |
|---|---|---|---|---|---|---|
COG A9961 (Packer et al. 2013) [31] | December 1996–2000, age 3–21 years, average-risk only | 397 | 15 | 7 | 2 (0.5) | 9.7 |
HIT’91 (Von Hoff et al. 2009) [42] | August 1991–December 1997, age 3–18 years | 280 | 12 | 4 | 1 (0.4) | 10 |
HIT-SIOP-PNET4 (Sabel et al. 2016) [36] | 2001–2006, age 4–21 years, average risk only | 338 | 3 | 2 | 1 (0.3) | 7.8 |
CCG 9892 (Packer et al. 1999) [30] | January 1990–December 1994, age 3–10 years, average risk only | 65 | 1 | 1 | 1 (1.5) | 4.7 |
Single institution (Michigan Medicine) | Pediatric patients diagnosed with medulloblastoma and treated between 2000 and 2015 | 77 | Not reported | Not reported | 3 (3.9) | Not reported |
Single institution (Seattle Children’s Hospital) | Pediatric patients diagnosed with medulloblastoma and treated between 2000 and 2015 | 91 | Not reported | Not reported | 1 (1.0) | Not reported |
Single institution (Hospital for Sick Children) | Pediatric patients diagnosed with medulloblastoma and treated between 2000 and 2015 | 140 | Not reported | Not reported | 1 (0.7) | Not reported |
Single institution (Princess Margaret Hospital for Children) | Pediatric patients diagnosed with medulloblastoma and treated between 2000 and 2015 | 41 | Not reported | Not reported | 1 (2.4) | Not reported |