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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: ABCA1 haplodeficiency affects the brain transcriptome following traumatic brain injury in mice expressing human APOE isoforms

Fig. 3

Abca1 deficiency affects the microglial response to TBI in an APOE isoform-dependent manner. a-b Heatmaps were generated using normalized Abca1+/− versus Abca1+/+ CPM values for each group for (a) microglia sensome genes and (b) synaptic transmission genes. Red denotes higher expression values, and blue denotes lower expression values. n = 6–8 per group, including both males and females. c, e Selected genes from the microglia sensome of APOE3/Abca1+/− and APOE3/Abca1+/+ mice are compared separately for (c) sham (black bars) and (e) TBI groups (green bars). Shown are the Log2-fold change values for each gene. d, f Selected genes from the microglia sensome of APOE4/Abca1+/+ and APOE4/Abca1+/− mice are compared separately for (d) sham (orange bars) and TBI groups (purple bars). Shown are the Log2-fold change values. *: p < 0.05

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Acta Neuropathologica Communications

ISSN: 2051-5960

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