Skip to main content

Table 4 Sample size and performed statistical analysis

From: Rac1 activation links tau hyperphosphorylation and Aβ dysmetabolism in Alzheimer’s disease

Figure Number Experiment Test Sample size (n) P value
Fig. 1a Rac1 AD human brain Mann Whitney 12, 24 0.028
Fig. 1b Rac1 human AD plasma Kruskal-Wallis
Dunn’s test
102, 47, 72, 42 0.0005
CTRL vs AD MMSE< 18 p = 0.0002; MCI vs AD MMSE< 18 p = 0.045; AD MMSE≥18 vs AD MMSE< 18p = 0.0051;
Fig. 3b SET/GluR1 Two-tailed One sample t test 10,10,10,6,6 CTRL vs Rac1-WT p = 0.039
CTRL vs Rac1-L61F37A, p = 0.037
Fig. 3d pT181/GAPDH Two-tailed One sample t test 9, 7, 7,3,3 CTRL vs Rac1-WT p = 0.023; CTRL vs Rac1-L61F37A, p = 0.014
Fig. 3d pT181/Tau5 Two-tailed One sample t test 9, 7, 7,3,3 CTRL vs Rac1-L61F37A, p = 0.045;
Fig. 5b Hippocampus 6 weeks Rac1GTP/Rac1 Student t test 4, 4 0.044
Fig. 5c Cortex 7 months Rac1/GAPDH Student t test 6, 6 0.005
Fig. 6a PSD95/Tuj1 One-way Anova
Turkey’s MC
8, 9, 8 0.0064
C57 + Veh vs 3xTgAD + Veh *
3xTgAD + Veh vs 3xTgAD + Rac1 *
Fig. 6d Spine density One-way Anova
Turkey’s MC
4, 4, 4 0.0061
C57 + Veh vs 3xTgAD + Veh *
3xTgAD + Veh vs 3xTgAD + Rac1 **
Additional file 1: Figure S2A Aβ toxicity Two-tailed One sample t test 4, 4, 4 Aβ0.1 μM 0.0044
Aβ0.5 μM 0.0088
Aβ1μM 0.0414
Additional file 1: Figure S4C 3 h OA Two-Tailed paired t test 6, 6 0.003
Additional file 1: Figure S4C 6 h OA Two-Tailed paired t test 4, 4 0.038
  1. *p < 0.05; **p < 0.01