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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Rac1 activation links tau hyperphosphorylation and Aβ dysmetabolism in Alzheimer’s disease

Fig. 6

Rac1 administration rescued dendritic impairment. a Representative immunoblots and (b) densitometry of PSD95 were normalized on Tuj1 in cortical homogenates of control mice (C57BL/6 J treated with vehicle) and 3xTg-AD mice treated with vehicle or with Rac1-L61F37A mutant peptide (100 μM) at 7 months old. Box and whiskers graphs represent boxes as min to max values, whiskers as standard errors and means as black lines. 10 μg of protein lysate were loaded. c Representative Golgi-cox stained dendrite portions with spines and (d) quantification of spine density (numbers of spine per μm of dendrite length) in the three condition analyzed (C57BL/6 J treated with vehicle: 1.32 ± 0.05 spines/μm; 3xTg-AD treated with vehicle: 1.17 ± 0.02 spines/μm; and 3xTg-AD treated with vehicle: 1.39 ± 0.03 spines/μm). The data represented are mean ± SEM

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