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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Rac1 activation links tau hyperphosphorylation and Aβ dysmetabolism in Alzheimer’s disease

Fig. 5

Rac1 is altered in 3xTg-AD mice. a, c Representative blots of active and total Rac1 protein levels in homogenates of 3xTg-AD mice and age-matched control mice. b, d Quantification of Rac1 protein activation (ratio between Rac1-GTP level and total Rac1), and total Rac1 level (total Rac1 on GAPDH ratio), at the 4 time points (6 weeks: C57BL/6 J n = 6, 3xTG-AD n = 6; 3 months: C57BL/6 J n = 4, 3xTG-AD n = 4; 7 months: C57BL/6 J N = 7, 3xTG-AD N = 7; 16 months: C57BL/6 J n = 5, 3xTG-AD n = 5). Box and whiskers graphs represent boxes as min to max values, whiskers as standard errors and means as black lines

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