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Table 1 Clinical and pathology details of cases and control groups (Further detail of each case is available in Additional file 1: Table S1)

From: Doublecortin-expressing cell types in temporal lobe epilepsy

Group

Tissue type

NUMBER

Predominant pattern of HS in body

Age (at surgery or death); mean (range, years)

Gender

Regions examined/study

Adult epilepsy TLE/HS (S1–13)

Surgical Fixed

13

ILAE Type 1 HS

41.3 (22–54)

7F: 6 M

HB,PES,PHG,TPole, TLobe, Amyg / qIHC

Paediatric epilepsy TLE/HS (S1–5)

Surgical Fixed

5

ILAE type 1 HS only

12.2 (8–15)

2F: 3 M

HB, TLobe / q IHC

Adult epilepsy TLE/NO HS (S19–24)

Surgical Fixed

6

NO HS

28.6 (24–35)

2F: 4 M

HB,PES,PHG,TPole, TLobe, Amyg / q IHC

Adult epilepsy (EPM1–16)

Post Mortem

16

ILAE type 1 HS in 8 CASES

48.7 (18–75)

8F: 8 M

HB, PHG, Amyg, Temporal Cortex (Both hemispheres included in 4 cases) / q IHC

Adult non-epilepsy controls (C1–12)

Post mortem

12

No HS

56.4 (28–85)

5F: 7 M

HB, PHG, Amyg, Temporal Cortex / q IHC

Adult epilepsy TLE/HS

Fresh

83

77a

All HS (16 with TLS)

All HS (15 with TLS)

36.3 (16–63)

35.6 (16–57)

45F-38M

39F-38M

Middle temporal gyrus (cortex) / RNA

Adult non-epilepsy controls

Fresh

73b

59a

No HS

No HS

50.8 (20–79)

28.8 (13–55)

14F–53F

30F-29M

Middle temporal gyrus (cortex)/ RNA

A1C, inferior and superior TC

  1. S surgical epilepsy case, EPM adult epilepsy post-mortem, C Post-mortem control, HB Hippocampal body, PES pes hippocampus, PHG parahippocampal gyrus, TPole temporal pole, TLobe temporal lobe, TLS temporal lobe sclerosis, Amyg amygdala, HS hippocampal sclerosis, qIHC qualitative and quantitative immunohistochemistry, RNAseq RNA sequencing and expression analysis, ILAE International League against epilepsy, TLE temporal lobe epilepsy.
  2. aOnly samples from adolescence and young and middle adulthood period. Controls from Kang et al.
  3. bSamples obtained from the MRC brain bank, Edinburgh. A1C = Primary auditory cortex