Fig. 1

Morphology of poly-GR and aDMA pathology. Immunohistochemistry for poly-GR reveals neuronal cytoplasmic inclusions in frontal cortex (a), CA2/3 (b), CA4 (c), DF (d), and cerebellar granular layer (e). Inclusions in glial cells were very rare (f). Immunohistochemistry for aDMA shows neuronal cytoplasmic inclusions, as well as variable nuclear immunoreactivity, which was dense in some neurons (g), moderate in others (h) and minimal in others (i); inclusions in CA2/3 (j), DF (k) and (l) cerebellar granular layer (n); neuronal nuclear inclusions (NII) (m); and rare glial cytoplasmic inclusions (n, o). Scale bar represents 20 μM. FCtx = frontal cortex, MCtx = Motor cortex, DF = dentate fascia, CA = hippocampal subfields, Cbl = cerebellar granular cell layer