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Table 1 Demographics of cases used in the study

From: The presubiculum is preserved from neurodegenerative changes in Alzheimer’s disease

Cases Disease group Gene/Mutations Age at onset Age at death Disease duration Sex Post-mortem delay (hours) Fixation time (weeks) Braak and Braak stage Thal phase CERAD score
1 SAD 63 73 10 M 31 7.14 6 5 Frequent
2 SAD 51 63 12 F 16 4.00 6 5 Frequent
3* SAD 51 62 11 F 63 2.71 6 5 Frequent
4 SAD 65 70 5 F 47 4.29 5 5 Moderate
5 SAD 64 77 13 M 90 3.14 6 5 Frequent
6 SAD 49 62 13 F 77 8.00 6 5 Frequent
7 SAD 72 88 16 M 86 3.29 6 5 Frequent
8 SAD 52 69 17 M 35 6.14 6 5 Frequent
9 SAD 65 72 7 M 39 3.00 5 5 Moderate
10 SAD 76 85 9 F 90 3.86 6 5 Frequent
11 SAD 55 64 9 M 77 3.43 6 5 Frequent
12 SAD 69 74 5 F 94 3.00 6 5 Frequent
13 SAD 80 85 5 M 129 n/a 5 5 Moderate
14 SAD 46 52 6 F 52 2.57 6 5 Frequent
15 SAD 49 54 6 F 48 4.29 6 5 Frequent
16 SAD 67 72 5 M 91 4.14 6 5 Frequent
17 SAD 65 79 14 F 23 3.43 6 5 Frequent
18 SAD 52 68 16 M 35 3.00 6 5 Frequent
19* SAD 58 68 10 M 52 3.86 6 5 Frequent
SAD summary 60.5 (10) 70.4 (9.8) 9.9 (4.1) 10 M:9F 61.8 (30) 4.1 (1.5) 5.8 (0.4) 5 (0) Frequent
20* FAD PS1 Intron 4 35 52 17 F 33 n/a 6 5 Frequent
21 FAD PS1 S132A 61 70 9 M n/a 4.29 5 5 Frequent
22 FAD PS1 Intron 4 42 51 9 M 43 4.00 6 5 Frequent
23* FAD APP V717 L 48 59 11 F 90 n/a 6 5 Frequent
24 FAD APP V717I 60 66 6 M 68 3.14 6 5 Frequent
25 FAD PS1 A434T/ T291A 42 47 5 M 44 4.29 5 5 Frequent
26 FAD PS1 R278I 46 66 20 F 32 4.86 6 5 Frequent
27 FAD PS1 I202F 48 59 11 F 26 4.00 6 5 Frequent
28 FAD PS1 E120K 33 37 4 F 24 6.00 6 5 Frequent
29 FAD APP V717I 44 56 12 F 16 4.29 6 5 Frequent
30 FAD PS1 Intron 4 39 47 8 F n/a n/a 6 5 Frequent
FAD summary 45.3 (8.9) 55.5 (9.9) 10.2 (4.9) 4 M:7F 53.7 (43.7) 4.4 (0.8) 5.8 (0.4) 5 Frequent
31 FBD BRI2 57 68 11 F 6.5 3.00 5 n/a n/a
32 FBD BRI2 n/a 56 n/a F n/a n/a 5 n/a n/a
33 FBD BRI2 n/a 65 n/a F n/a n/a 5 n/a n/a
34 FBD BRI2 n/a 60 n/a M n/a n/a 5 n/a n/a
FBD summary 57 62.3 (5.3) 11 1 M:3F 6.5 3.00 5 n/a n/a
36 FDD BRI2 25 43 18 M n/a n/a 5 n/a n/a
37 FDD BRI2 34 60 26 F n/a n/a 5 n/a n/a
38 FDD BRI2 40 58 18 M n/a n/a 5 n/a n/a
39 FDD BRI2 21 53 32 M n/a n/a 5 n/a n/a
FDD summary 30 (8.6) 53.5 (7.6) 23.5 (6.8) 2 M:1F n/a n/a 5 n/a n/a
  1. All cases were used for morphological analysis of the presubiculum. ‘*’ cases used for proteomics