Table 1 Demographics of cases used in the study
From: The presubiculum is preserved from neurodegenerative changes in Alzheimer’s disease
Cases | Disease group | Gene/Mutations | Age at onset | Age at death | Disease duration | Sex | Post-mortem delay (hours) | Fixation time (weeks) | Braak and Braak stage | Thal phase | CERAD score |
|---|---|---|---|---|---|---|---|---|---|---|---|
1 | SAD | – | 63 | 73 | 10 | M | 31 | 7.14 | 6 | 5 | Frequent |
2 | SAD | – | 51 | 63 | 12 | F | 16 | 4.00 | 6 | 5 | Frequent |
3* | SAD | – | 51 | 62 | 11 | F | 63 | 2.71 | 6 | 5 | Frequent |
4 | SAD | – | 65 | 70 | 5 | F | 47 | 4.29 | 5 | 5 | Moderate |
5 | SAD | – | 64 | 77 | 13 | M | 90 | 3.14 | 6 | 5 | Frequent |
6 | SAD | – | 49 | 62 | 13 | F | 77 | 8.00 | 6 | 5 | Frequent |
7 | SAD | – | 72 | 88 | 16 | M | 86 | 3.29 | 6 | 5 | Frequent |
8 | SAD | – | 52 | 69 | 17 | M | 35 | 6.14 | 6 | 5 | Frequent |
9 | SAD | – | 65 | 72 | 7 | M | 39 | 3.00 | 5 | 5 | Moderate |
10 | SAD | – | 76 | 85 | 9 | F | 90 | 3.86 | 6 | 5 | Frequent |
11 | SAD | – | 55 | 64 | 9 | M | 77 | 3.43 | 6 | 5 | Frequent |
12 | SAD | – | 69 | 74 | 5 | F | 94 | 3.00 | 6 | 5 | Frequent |
13 | SAD | – | 80 | 85 | 5 | M | 129 | n/a | 5 | 5 | Moderate |
14 | SAD | – | 46 | 52 | 6 | F | 52 | 2.57 | 6 | 5 | Frequent |
15 | SAD | – | 49 | 54 | 6 | F | 48 | 4.29 | 6 | 5 | Frequent |
16 | SAD | – | 67 | 72 | 5 | M | 91 | 4.14 | 6 | 5 | Frequent |
17 | SAD | – | 65 | 79 | 14 | F | 23 | 3.43 | 6 | 5 | Frequent |
18 | SAD | – | 52 | 68 | 16 | M | 35 | 3.00 | 6 | 5 | Frequent |
19* | SAD | – | 58 | 68 | 10 | M | 52 | 3.86 | 6 | 5 | Frequent |
SAD summary | 60.5 (10) | 70.4 (9.8) | 9.9 (4.1) | 10 M:9F | 61.8 (30) | 4.1 (1.5) | 5.8 (0.4) | 5 (0) | Frequent | ||
20* | FAD | PS1 Intron 4 | 35 | 52 | 17 | F | 33 | n/a | 6 | 5 | Frequent |
21 | FAD | PS1 S132A | 61 | 70 | 9 | M | n/a | 4.29 | 5 | 5 | Frequent |
22 | FAD | PS1 Intron 4 | 42 | 51 | 9 | M | 43 | 4.00 | 6 | 5 | Frequent |
23* | FAD | APP V717 L | 48 | 59 | 11 | F | 90 | n/a | 6 | 5 | Frequent |
24 | FAD | APP V717I | 60 | 66 | 6 | M | 68 | 3.14 | 6 | 5 | Frequent |
25 | FAD | PS1 A434T/ T291A | 42 | 47 | 5 | M | 44 | 4.29 | 5 | 5 | Frequent |
26 | FAD | PS1 R278I | 46 | 66 | 20 | F | 32 | 4.86 | 6 | 5 | Frequent |
27 | FAD | PS1 I202F | 48 | 59 | 11 | F | 26 | 4.00 | 6 | 5 | Frequent |
28 | FAD | PS1 E120K | 33 | 37 | 4 | F | 24 | 6.00 | 6 | 5 | Frequent |
29 | FAD | APP V717I | 44 | 56 | 12 | F | 16 | 4.29 | 6 | 5 | Frequent |
30 | FAD | PS1 Intron 4 | 39 | 47 | 8 | F | n/a | n/a | 6 | 5 | Frequent |
FAD summary | 45.3 (8.9) | 55.5 (9.9) | 10.2 (4.9) | 4 M:7F | 53.7 (43.7) | 4.4 (0.8) | 5.8 (0.4) | 5 | Frequent | ||
31 | FBD | BRI2 | 57 | 68 | 11 | F | 6.5 | 3.00 | 5 | n/a | n/a |
32 | FBD | BRI2 | n/a | 56 | n/a | F | n/a | n/a | 5 | n/a | n/a |
33 | FBD | BRI2 | n/a | 65 | n/a | F | n/a | n/a | 5 | n/a | n/a |
34 | FBD | BRI2 | n/a | 60 | n/a | M | n/a | n/a | 5 | n/a | n/a |
FBD summary | 57 | 62.3 (5.3) | 11 | 1 M:3F | 6.5 | 3.00 | 5 | n/a | n/a | ||
36 | FDD | BRI2 | 25 | 43 | 18 | M | n/a | n/a | 5 | n/a | n/a |
37 | FDD | BRI2 | 34 | 60 | 26 | F | n/a | n/a | 5 | n/a | n/a |
38 | FDD | BRI2 | 40 | 58 | 18 | M | n/a | n/a | 5 | n/a | n/a |
39 | FDD | BRI2 | 21 | 53 | 32 | M | n/a | n/a | 5 | n/a | n/a |
FDD summary | 30 (8.6) | 53.5 (7.6) | 23.5 (6.8) | 2 M:1F | n/a | n/a | 5 | n/a | n/a | ||