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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Sporadic Parkinson’s disease derived neuronal cells show disease-specific mRNA and small RNA signatures with abundant deregulation of piRNAs

Fig. 5

Analysis of tissue samples underscores the relevance of piRNAs in PD. a Histology of a cingulate gyrus section of a healthy control, a substantia nigra section from a PD-patient (PD-patient 8 from the tissue cohort) and a cingulate gyrus section of the same patient all stained with an antibody directed against aggregated α-synuclein. Lewy bodies are present both in the cingulate gyrus as well as in the substantia nigra of the PD-patient. b Analysis of differential mRNA, mature miRNA and piRNA expression by DESeq2. There are significant differences between control- and PD-patients in every type of RNA. c Venn diagram of all common upregulated and downregulated mature miRNAs (log2FC ≥ 0.6, p-adj. < 0.1) in tissues and neurons. d Semiquantitative PCR of PIWIL2 and PIWIL4 in the tissues used for the analysis of small RNA expression patterns. Both genes are expressed in cingulate gyrus tissue. GAPDH was used as a loading control. A 100 bp DNA-ladder (M) was loaded together with the PCRs from control (CTRL) and PD-patient (PD) cingulate gyrus samples

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