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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: The age of onset and evolution of Braak tangle stage and Thal amyloid pathology of Alzheimer’s disease in individuals with Down syndrome

Fig. 1

Pathological changes in Down syndrome. In case #8, aged 13 years, amyloid deposits are present in the temporal cortex as diffuse plaques in the absence of any tau pathology (a). A few tau positive neurites are present in locus caeruleus in case #14 (b) and a single tau positive neurofibrillary tangle is seen, again in locus caeruleus, in case #20 (c), in the absence of any tau pathology elsewhere in the brain. A few α-synuclein positive Lewy bodies (d) and Lewy neurites (e) are present in the substantia nigra in case #45, aged 62 years, but these are more densely present in entorhinal cortex (f) and temporal neocortex (g) of the same case. Sparse TDP-43 neuronal cytoplasmic inclusions (arrowed) are seen in dentate gyrus granule cells in case #43, aged 61 years (h). Immunoperoxidase-haematoxylin; × 250 microscope magnification (a) × 400 microscope magnification (bh)

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