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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Neuropathology and cognitive performance in self-reported cognitively healthy centenarians

Fig. 5

Representative neuropathological lesions found in the hippocampus (a, d, g, j), middle temporal lobe cortex (b, e, h, i, k), amygdala (c) and frontal lobe cortex (f) of case 100069. Shown are exemplary pTDP-43 accumulations (a-c) in the hippocampal subregion CA1 (a1) and dentate gyrus (DG) (a2), temporal pole cortex (T) (b) and Amygdala (Amy) (c), Aβ positivity (d-f) in the form of diffuse and classical plaques in the hippocampal CA1 region (d) and temporal pole cortex (e), as well as CAA of large vessels and capillaries in the frontal lobe (F2) (f). pTau immuno-staining (g-i) is shown as (pre)tangles and neuritic plaque like structures in the hippocampal CA1 region (g) and temporal pole cortex (h1 and h2), as well as astroglial pTau in ARTAG in the temporal pole cortex (i1 and i2). GVD (CK1δ granules) (j-k) is shown in the hippocampus (j) and temporal pole cortex (k). Scale bar 25 μm

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