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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Phosphorylation of different tau sites during progression of Alzheimer’s disease

Fig. 4

Quantification of tau phosphorylation at pSer396, pSer262 and pSer422 in the cortex of AD cases. a Human pSer396 tau immunoreactive area in percent in the isocortex and TEntR (allocortex) of different AD stages. c Human pSer422 tau immunoreactive area in percent in the isocortex and TEntR of different AD stages. e Human pSer262 tau immunoreactive area in percent in the isocortex and TEntR of different AD stages. Isocortical data in a, c and e present mean of different cortical regions that are shown separately in b, d and f, respectively. Two way ANOVA followed by Bonferroni’s posthoc test. Mean + SEM; N = 5.*p < 0.05; **p < 0.01; ***p < 0.001. Solid lines: Comparison of AD stages within a brain region; dotted lines: comparison of brain regions of the same AD Braak stage. CiCtx: cingulate cortex; FrCtx: frontal cortex; OcCtx: occipital cortex; TeCtx: temporal cortex; TEntR: transentorhinal region

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