Fig. 1
From: Phosphorylation of different tau sites during progression of Alzheimer’s disease
Quantification of total human tau and plaque load in the cortex of AD cases. a Total human tau (HT7 antibody) immunoreactive area in percent in the isocortex and TEntR (allocortex) of different AD stages. c β sheet (ThioflavinS staining) positive area in percent in the isocortex and TEntR of different AD stages. Isocortical data in a and c present mean of different cortical regions that are shown separately in b and d, respectively. Two way ANOVA followed by Bonferroni’s posthoc test. Mean + SEM; N = 5.*p < 0.05; **p < 0.01; ***p < 0.001. c, d One outlier of Braak stage V/VI excluded for all ThioS labelings. Solid lines: Comparison of AD stages within a brain region; dotted lines: comparison of brain regions of the same AD Braak stage. CiCtx: cingulate cortex; FrCtx: frontal cortex; OcCtx: occipital cortex; TeCtx: temporal cortex; TEntR: transentorhinal region