Fig. 2
From: Dipeptide repeat proteins activate a heat shock response found in C9ORF72-ALS/FTLD patients
Activation of HSF1 in C9ORF72-ALS, FTLD, and combined ALS/FTLD patients. a Quantitative real-time PCR (qRT-PCR) for HSF1 target genes in the frontal cortex of sporadic and C9ORF72-associated disease (n = 56 C9ORF72-ALS/FTLD, n = 46 sporadic ALS/FTLD, n = 9 controls) (one-way ANOVA with Bonferonni post-hoc test for multiple comparisons, *p < 0.05, **p < 0.01, ***p < 0.001). No significant changes were detected between the sporadic cases and controls (mean values for each gene are provided in Additional file: 3 Table S3). b qRT-PCR for HSF1 in the frontal cortex and cerebellum of these same cases