Fig. 1

Identification of specific cellular pathways perturbed in sporadic ALS and C9ORF72-ALS a Diagram of RNA-seq datasets obtained from the frontal cortex and cerebellum by Prudencio et al. b Comparison of the significant (FDR < 0.05) differentially expressed transcripts in C9ORF72-ALS (C9-ALS) and sporadic ALS (sALS). Note, there were no common transcripts between C9ORF72-ALS and sporadic ALS in either brain region. c Comparison of the differentially expressed transcripts by brain region. d Correlation of the fold change (log2) of changed transcripts in C9ORF72-ALS that were common to both brain regions (Spearman’s R²) e, f Gene ontology (GO) analysis revealed cellular processes affected in C9ORF72-ALS and sALS. g Protein-protein interaction analysis of proteins encoded by the transcripts changed in C9ORF72-ALS revealed a protein chaperone network