Fig. 7
Effects of efk-1 deletion on ethanol avoidance, pharyngeal pumping, and area restricted searching behavior in C. elegans expressing human AS-A53T. a-c Analysis of ethanol avoidance (n = 100–150 worms/measurement) (a), pharyngeal pumping (n = 10–15 worms/measurement) (b), and area restricted searching behavior (n = 10–15 worms/measurement) (c) in control (wild type N2) worms, in efk-1(ok3609) null mutant worms (efk-1del), in worms expressing human mutant AS-A53T (Pdat-1::a-synuclein[A53T]), and in efk-1(ok3609) null mutant worms expressing AS-A53T (efk-1(ok3609); Pdat-1::a-synuclein[A53T]). Statistical analysis: one-way ANOVA with post-hoc Bonferroni test; *p < 0.05, ***p < 0.005, NS = not significant; error bars indicate mean ± S.E.M. from at least three independent experiments