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Table 2 Gene-ontology terms upregulated in adult GBM tumor-associated macrophages compared to DIPG tumor-associated macrophages

From: Non-inflammatory tumor microenvironment of diffuse intrinsic pontine glioma

GO Terms upregulated in aGBM TAMs vs. DIPG TAMs
GO Term p-value Genes
Inflammatory response 4.70E-13 NFKBIZ, IL6, CCL3, OLR1, PTGS2, CXCL2, CXCL8, NFKB1, NLRP3, CCL5, CCL4, CCRL2, FOS, IL1B, NAIP, CLEC7A, NFE2L2, TNFAIP3, IL1A
Positive regulation of smooth muscle cell proliferation 5.66E-07 NAMPT, IL6, EREG, PTGS2, HBEGF, NR4A3, CCL5
Cellular response to interleukin-1 1.55E-06 ICAM1, IL6, CCL3, CXCL8, NFKB1, CCL5, CCL4
Positive regulation of transcription from RNA polymerase II promoter 1.57E-06 EGR1, NAMPT, IL6, EGR2, CCNH, NR4A2, CCNL1, NFKBIA, NFKB1, FOSB, NR4A3, NLRP3, FOS, ATF3, RGCC, IL1B, NFE2L2, IL1A, KLF4
Immune response 8.70E-06 GPR183, IL6, CCL3, CXCL2, IL1RN, CXCL8, IL1B, CCL5, SLED1, CCL4, GBP2, IL1A
Cellular response to tumor necrosis factor 1.98E-05 ICAM1, IL6, CCL3, CXCL8, NFE2L2, CCL5, CCL4
Chemokine-mediated signaling pathway 2.96E-05 CCRL2, CCL3, CXCL2, CXCL8, CCL5, CCL4
Positive regulation of gene expression 5.38E-05 IL6, LIMS1, CCL3, RGCC, MDM2, IL1B, NFE2L2, KLF4, IL1A