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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Non-inflammatory tumor microenvironment of diffuse intrinsic pontine glioma

Fig. 4

Patient-derived DIPG and aGBM cell cultures exhibit distinct cytokine secretion profiles (a) Hierarchical clustering of mean fluorescence intensity values of secreted factors in conditioned medium derived from patient-derived DIPG (red), aGBM (blue), pediatric GBM (green), and human neural precursor cell (hNPC) cultures (orange). Each column represents the average of samples tested in triplicate, and each row represents a separate measured cytokine (b-c) Box and whisker plot of FPKMs of cytokines and chemokines from patient-derived DIPG cell cultures (b) and primary bulk DIPG tissue (c) RNA sequencing data [11, 30, 35]. Dashed line represents FPKM = 5 (d) Violin plots of gene expression from single-cell RNA sequencing of diagnostic DIPG biopsy samples [7]. Dashed line represents log(tpm + 1) = 1

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