Fig. 5

Sequential distribution patterns of white matter ARTAG in the pooled cohort of non-FTLD-tauopathies. Pattern 1 (a) is characterized by the appearance of white matter ARTAG in basal brain regions (stage 1) followed by lobar regions (stage 2a) or eventually brainstem (stage 2b) before involving all regions (stage 3). In Pattern 2 (b) lobar involvement (stage 1) is followed by the involvement of the basal brain regions or the brainstem (stages 2 a or b, respectively), before involving all regions (stage 3)