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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Environmental enrichment reverses Aβ pathology during pregnancy in a mouse model of Alzheimer’s disease

Fig. 5

Decreased adult neurogenesis in pregnant and lactating WT and 5xFAD female mice at P20. a Fluorescence microscopy of DCX (green) and DAPI (blue). Shown are representative images of the dentate gyrus from 5xFAD female mice sacrificed at the postpartum day 20 (P20). Inserts show higher magnifications. b Quantification of DCX positive cells displayed significant reductions in pregnant and lactating WT and 5xFAD female mice at P20. Mann-Whitney test, **P = 0.0015, Kruskal-Wallis test followed by Dunn’s multiple comparison test, **P = 0.0089, *P = 0.012. c Quantification of Ki67 positive cells exhibited significant reductions in pregnant and lactating WT and 5xFAD female mice at P20. Mann-Whitney test, **P = 0.0047, Kruskal-Wallis test followed by Dunn’s multiple comparison test, *P = 0.02. d Fluorescence microscopy of Ki67 (green) and DAPI (blue). Shown are representative images of the dentate gyrus from 5xFAD female mice sacrificed at P20. White arrows indicate the presence of Ki67 positive cells. Inserts show higher magnifications. Scale bar represents 100 μm in the overview and 20 μm in the inserts. Data are presented as mean ± S.D. Each symbol represents data from one mouse, with five to seven mice per group. P = postpartum day, DCX = doublecortin

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