Fig. 2

Unaltered Aβ plaque load in 10 months old nulliparous and multiparous 5xFAD female mice. a Schematic overview of the experimental setup. Twelve weeks old 5xFAD female mice were bred and sacrificed at the age of 10 months. Females had either no litter or 4 litters. b Fluorescence microscopy of Aβ (red) and DAPI (blue). Shown are representative images of hippocampi from nulliparous and multiparous female 5xFAD mice. c Quantification of Aβ plaque load (left) and compact Aβ plaque load (right) of nulliparous and multiparous 5xFAD mice showed no differences between the groups. Data are presented as mean ± S.D. Each symbol represents data from one mouse, with five mice per group. Scale bar represents 500 μm. L = litter