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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Loss of Tmem106b is unable to ameliorate frontotemporal dementia-like phenotypes in an AAV mouse model of C9ORF72-repeat induced toxicity

Fig. 5

(GGGGCC)66 repeat expansion overexpression does not alter Tmem106b protein levels in mouse brain. (a) Western blot of brain tissue obtained from 2R- or 66R-injected wild-type mice using antibodies against various lysosomal proteins. Gapdh was used as a loading control. (b) Quantification of Tmem106b protein levels by Western blot as depicted in panel a. The graph represents the mean ± S.E.M. by Student’s t-test (n = 8 for 2R; n = 12 for 66R ); NS, not significant

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