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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Loss of Tmem106b is unable to ameliorate frontotemporal dementia-like phenotypes in an AAV mouse model of C9ORF72-repeat induced toxicity

Fig. 3

Assessment of (GGGGCC)66-mediated neuropathology in response to changes in Tmem106b levels (a-b) Quantification of Iba1 (a) or Gfap (b) mRNA levels in the cortex of 2R-injected mice, or in 66R-injected Tmem106b +/+, +/−, or −/− mice. c Quantitative analysis of the number of cells immunoreactive for NeuN in the cortex of 2R-injected mice, or in 66R-injected Tmem106b +/+, +/−, or −/− mice. d Image depicting the presence of RNA foci (arrowheads) in the nuclei of cortical cells in wild-type 66R- versus 2R-injected mice. e Quantification of the number of cells with RNA foci in the cortex of wild-type 2R-injected mice, or in 66R-injected Tmem106b +/+, +/−, or −/− mice. f Quantitative assessment of the presence of poly(GP) peptides detected in the brains of mice injected as described in panel e. Graphs represent the mean ± S.E.M. Data was analyzed by one-way ANOVA followed by Fisher’s LSD post-hoc, and results are shown for 66R-injected Tmem106b +/− and −/− mice as compared to 66R-injected wild-type mice (n = 12 per group). NS, not significant.; *p < 0.05; **p < 0.001

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