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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Loss of Tmem106b is unable to ameliorate frontotemporal dementia-like phenotypes in an AAV mouse model of C9ORF72-repeat induced toxicity

Fig. 2

(GGGGCC)66 repeat-induced behavioral deficits are unchanged by Tmem106b reduction. a Quantification of the average distance traveled obtained during the open field assay for 66R-injected Tmem106b +/+, +/−, −/− mice at 12 months of age. Wild-type mice of the same age that had been injected with 2R C9ORF72 were used as a control. b Quantification of the average speed traveled during the open field assay for mice as described in (a). c-d Quantification of the time each mouse spent freezing during the contextual (c) and cued (d) fear conditioning tests. e Quantification of the time each mouse spent exploring the mouse-containing cup during the social interaction test (f qPCR quantification measuring the amount of 66R mRNA obtained from the brains of 12-month-old 66R-injected Tmem106b +/+, +/−, and −/− mice. Graphs represent the mean ± S.E.M. Data was analyzed by one-way ANOVA followed by Fisher’s LSD post-hoc, and results are shown for 66R-injected Tmem106b +/− and −/− mice as compared to 66R-injected wild-type mice (n ≥ 12 for all groups). NS, not significant

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