Fig. 5

Genes located on rarely mutated chromosomal arms with strong impact on signaling and metabolic pathways. Impacts of differentially expressed genes of rarely mutated chromosomal arms (Table 1) on the expression of known cancer-relevant signaling pathway genes (a–f) and metabolic pathway genes (g–i). All shown genes had significantly greater impacts under the oligodendroglioma-specific gene regulatory networks than under corresponding random networks of same complexity (q-value ≤0.1). Genes colored in green were underexpressed and genes colored in red were overexpressed in oligodendrogliomas with the corresponding chromosomal arm mutation in comparison to normal brain tissue