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Fig. 9 | Acta Neuropathologica Communications

Fig. 9

From: Astrocyte remodeling without gliosis precedes optic nerve axonopathy

Fig. 9

RGC axon functional deficits are associated with astrocyte connectivity in DBA/2 J optic nerve. a. Higher levels of Cx43 are associated with a greater degree of parallelism of GFAP-labeled astrocyte processes in proximal segments of DBA/2 J nerve (left, R = 0.66; p = 0.04) but not distal (right, R = 0.11; p = 0.77). b Intact anterograde transport to the superior colliculus is well-predicted by levels of Cx43 in the distal optic nerve (right, R = 0.88; p < 0.001), but not proximal (left, R = 0.39; p = 0.23). Scale: 100 μm (a)

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