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Fig. 8 | Acta Neuropathologica Communications

Fig. 8

From: A53T-α-synuclein overexpression in murine locus coeruleus induces Parkinson’s disease-like pathology in neurons and glia

Fig. 8

No SN cell loss after 9 weeks of A53T-aSYN overexpression in LC region. a Abundant human aSYN-positive (red, upper right) axons were observed in the TH-positive SN region (green, upper left) after 9 weeks of A53T-aSYN overexpression in the LC. In contrast, no aSYN-positive cell bodies could be detected. b Quantification of TH-positive SN neurons 9 weeks post injection revealed no significant difference between A53T-aSYN group (red bars) and Luc control group (black bars) for either side. Values are presented as mean ± SEM, n = 8 per group and side. One-way ANOVA analysis (p > 0.05). c Representative image of TH and human aSYN axonal co-localization in distant brain regions, exemplified for midbrain reticular nucleus (MRN). The majority of aSYN positive axons co-stained for TH indicating that they origin from the LC. Scale bars 250 μm in a, 25 μm in c

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