Fig. 7

Widespread transport of human A53T-aSYN to interconnected brain regions. a-d Representative images of analyzed brain sections stained against human aSYN (Syn211) (Bregma + 0.50 mm a, Bregma − 0.94 mm b, Bregma − 3.16 mm c, Bregma − 7.56 mm d). Scale bars 1 mm in a-d, 25 μm in all high magnification images. Abbreviations: CTX, cortex; CP, caudoputamen; LS, lateral septal nucleus; MS, medial septal nucleus; aco, anterior commissure; BST, bed nuclei of stria terminalis; HY, hypothalamus; SI, substantia innominata; OT, olfactory tubercle; HPF, hippocampal formation; DG, dentate gyrus; fi, fimbria hippocampi; int, internal capsule; TH, thalamus; GP, globus pallidus; sAMY, striatum-like amygdalar nuclei; LHA, lateral hypothalamic area; CEA, central amygdalar nucleus; SC, superior colliculus; APN, anterior pretectal nucleus; PAG, periaqueductal gray; MRN, midbrain reticular nucleus; VTA, ventral tegmental area; SNc, substantia nigra pars compacta; SNr, substantia nigra pars reticulata; AP, area postrema; NTS, nucleus of the solitary tract; CU, cuneate nucleus; ECU, external cuneate nucleus; DMX, dorsal motor nucleus of the vagus nerve; XII, hypoglossal nucleus; SPV, spinal nucleus of the trigeminal; MDRNd, medullary reticular nucleus, dorsal part; MDRNv, medullary reticular nucleus, ventral part; IRN, intermediate reticular nucleus; IO, inferior olivary complex; py, pyramid; RA, raphe nuclei; mlf, medial longitudinal fascicle; LRN, lateral reticular nucleus; sptV, spinal tract of the trigeminal nerve; icp, inferior cerebellar peduncle; L, left (contralateral); R, right (ipsilateral)