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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: A53T-α-synuclein overexpression in murine locus coeruleus induces Parkinson’s disease-like pathology in neurons and glia

Fig. 5

p62- and Ubi-1 positive aggregates co-localize with IbA1-positive microglia. a-c Representative confocal microscopy images of p62 (green, second column) and MAP2 (a, red, first row), Olig2 (b, gray, second row), or GFAP (c, red, third row) show no co-localization of p62 and the different cellular markers. In contrast, co-staining p62 (green) and IbA1 (d, gray, fourth row) or Ubi-1 (green) and IbA1 (e, gray, fifth row) revealed clear co-localization. IbA1 positive microglial cells (f, gray, sixth row) and GFAP-positive astroglia (g, red, seventh row) also co-stained for aSYN (arrows in f, g). Scale bar for a-g 25 μm

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