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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Proteomics analysis identifies new markers associated with capillary cerebral amyloid angiopathy in Alzheimer’s disease

Fig. 5

Immunohistochemical analysis of selected proteins. Representative images were taken. Aβ pathology was visualized. a The control case does not have any Aβ pathology. b Plaque pathology is confirmed in the AD case and (c) CAA type-1 pathology is confirmed in the CAA type-1 case. d-f Extensive NDP immunoreactivity is observed in the CAA type-1 cases whereas absent in both control and AD cases without CAA. g-i COL6A2 immunoreactivity is hardly observed in the control and AD cases, however, extensive immunoreactivity is observed in the CAA type cases and includes both capillaries and large vessels. j-l Immunoreactivity for HTRA1 is absent in control tissue, however, is observed both related to plaque pathology and CAA at comparable intensity. m-o Immunoreactivity for APCS is absent in control cases but is observed both related to plaque and CAA type-1 pathology. However, the intensity of the staining observed in the AD cases is considerably less. p-r Also, APOE immunoreactivity is observed related to both plaque and CAA type-1 pathology, yet its intensity in CAA type-1 is far greater. Scale bar, 100 μm in images A to R. Scale bar in image (C`) 10 μm and in all zoomed images, which are marked with a grave accent (`)

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