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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: D409H GBA1 mutation accelerates the progression of pathology in A53T α-synuclein transgenic mouse model

Fig. 3

D409H GBA1 expression shortens lifespan and leads to dopaminergic degeneration in the hA53T α-synuclein transgenic mice. a, Survival was monitored from littermates with the following genotypes: hA53Ta-Syn/GBA1+/+ (n = 15), hA53T α-Syn/GBA1+/D409H(n = 16), hA53T α-Syn/GBA1D409H/D409H (n = 18) mice. GBA1 mutation induces the lethal phenotype and TH-positive neuronal loss in the SNpc of A53T mutant α-synuclein transgenic mice. b and c, The number of TH-positive neurons in the SNpc was counted using stereological analysis with the indicated genotypes at 6 months of age. The scale bar is 200 μm. DATA are expressed as mean ± SEM (n = 6 for the each group)

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Acta Neuropathologica Communications

ISSN: 2051-5960

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