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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: D409H GBA1 mutation accelerates the progression of pathology in A53T α-synuclein transgenic mouse model

Fig. 2

The levels of α-synuclein are dependent on GBA1 enzyme activity. a and b, The expression levels of GBA1 were quantified in the ventral midbrain of the indicated genotypes at 6 months of age. c, GBA1 enzyme activity assay was conducted in the ventral midbrain of the indicated genotypes at 6 months of age. d, Dot blot shows relative GlcCer levels in the ventral midbrain of the indicated genotypes at 6 months of age. e, The relative levels of GlcCer were quantified. f, Representative images of GlcCer by immunostaining in the SN of the indicated genoypes at 6 months of age. The scale bar is 200 μm. g, Steady-state levels of human and mouse α-synuclein were monitored in the ventral midbrain of the indicated genotypes via Western blot analysis at 6 months of age. h and i, The expression levels of human and mouse α-synuclein were quantified. DATA are expressed as mean ± SEM (n = 6 for the each group)

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