Fig. 1From: D409H GBA1 mutation accelerates the progression of pathology in A53T α-synuclein transgenic mouse modelBreeding strategy. To test our hypothesis that decreased GBA1 enzyme activity affects neurodegeneration in human A53T α-synuclein mouse model of PD, the GBA1D409H/D409H knock-in mice were crossbred with the hA53T α-synuclein miceBack to article page