Fig. 3
From: α-Synuclein fibril-induced paradoxical structural and functional defects in hippocampal neurons
Spontaneous synaptic activity driven by action potentials is normal in neurons with α-syn inclusions. EPSCs were analyzed over 10 min in neurons 7 days following exposure to fibrils (DIV14) or control neurons in the absence or presence of PTX, 100 μM, to isolate excitatory currents. sEPSCs were recorded from the same neurons as the mEPSC recordings in Fig. 1. Burst events were detected with a threshold of 100 pA. There were no significant differences in the frequency or amplitude of burst events. Unpaired t-tests, control cells (N = 11) and fibril-treated neurons (N = 8)