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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Systemic inhibition of the membrane attack complex impedes neuroinflammation in chronic relapsing experimental autoimmune encephalomyelitis

Fig. 5

C6 antisense-mediated MAC inhibition protects from axonal damage. Richardson’s staining on spinal cord tissue from no drug mice showed wide areas of axonal damage corresponding to the lesioned areas (a). Electron microscopy micrograph indicates the types of axonal damage detected and quantified: 1. destruction of the myelin sheathe, 2. deformation of the myelin sheathe with gaps between tangent layers, 3. infoldings of the myelin sheathe within the axoplasmic area, and 4. onion bulbs (b). Picture of Richardson’s stained spinal cord section and electron microscopy micrograph from C6 antisense-treated mice (c-e) showing rarely detected damaged axons (arrows in c, d and arrows in e). Graph shows the percentage of axonal damage as quantified in the ventral and lateral column of the cervical and thoracic spinal cord segments from control (n = 6), no drug (n = 4) or C6 antisense-treated (n = 6) mice, collected post-relapse. Comparisons between groups were performed using the Kruskal-Wallis test by ranks. Data are expressed as the average (mean) ± SEM. Statistical differences are indicated (***p < 0.001) (f). Pictures from control mice showed intact axons only (g, h). Scale bars: (a, c, g) 25 μm, (b, e) 2 μm, (d) 500 nm (h) 200 nm

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